職稱：副教授、碩士生導師

學歷：博士研究生

電話：14759759282

電子郵件：juanyang@fzu.edu.cn

研究方向：蛋白質化學 結構生物學

教育工作經歷：

2019.06—至今     福州大學，生物科學與工程學院   副教授

2015.05—2019.05  福州大學，生物科學與工程學院   講師

2011.09—2015.04  廈門大學，化學生物學專業理學   博士

2011.04—2011.09  中國科學院上海藥物研究所交流學習

2008.09—2011.03  華東理工大學，制藥工程與技術專業工學  碩士

2004.09—2008.07  鄭州大學，制藥工程專業工學      學士

教學簡介：

講授本科生課程：《基因工程》、《結構生物學》和《常用生物工程軟件應用》

承擔本科生實驗課程：《免疫組化實驗》

科研簡介：

主要從事疾病相關的蛋白質靶點與藥物之間相互作用的構效關系及藥物調控機制的研究，將結構生物學、分子生物學、細胞生物學與生物化學等研究手段相結合，從藥物與靶標的構效關系、藥物作用的生理和病理機制以及藥物調控的分子機理等方面開展研究，為新藥的研發提供結構基礎和理論指導。目前已在Molecular Microbiology，Org.Lett.，Synthesis，J.Med.Chem.，Nat. Prod. Bioprospect，Protein expression and purification，Acta Biochim Biophys Sin等國際學術期刊上發表SCI論文多篇，并獲得國內發明專利兩項。

科研項目：

1. 國家自然科學基金（青年基金），人源程序性死亡受體PD-1與其配體PD-L2負性調控免疫應答的結構基礎研究，項目編號31700656，項目起止時間2018.01—2020.12，主持；

2. 福建省自然科學基金（青年基金），人程序性死亡配體PD-1與其配體PD-L2調節免疫應答的結構基礎和功能研究，項目編號2017J05050，項目起止時間 2017.04-2020.04，主持；

3. 福州大學校人才項目，人源B7家族PD-1-PD-L2通路調節免疫應答的結構基礎，項目起止時間2015.5—2017.5，主持。

代表性論文：（*為通訊作者）

1. Juanjuan Yang, Jing Hong, Ling Luo, Ke Liu, Chun Meng, Zhi-liang Ji, Donghai Lin*. Biophysical characterization and ligand-binding properties of the elongation factor Tu from Mycobacterium tuberculosis. Acta Biochim Biophys Sin, 2019, 51(2):139-149.

2. Yunbao Zhi, Yazhuang Dai, Juanjuan Yang, Shuhua Tan, Donghai Lin, Kejiang Lin*. Lead compounds and key residues of ribosomal protein S1 in drug-resistant Mycobacterium tuberculosis.Bioorganic Chemistry, 2019, 82: 58-67.

3. Yang Yang, Zhen Liu, Xiaoqin He, Juanjuan Yang, Jing Wu, Hailong Yang, Min Li, Qian Qian, Ren Lai*, Wei Xu* and Lin Wei*. A small mycobacteriophage-derived peptide and its improved isomer restrict mycobacterial infection via dual mycobactericidal-immunoregulatory activities. Journal of Biological Chemistry, 2019, 294(19): 7615-7631.

4. Taotao Chen, Zheng Chen, Huimin Wang, Xiaodong Chen, Juanjuan Yang, Aidong Han, Dong-Hai Lin, Jing Hong*. Underlying action mechanism of a novel antioxidant peptide derived from Allium tuberosum Rottler protein hydrolysates and its protective e?ects on hydrogen peroxide induced cell injury. Journal of Functional Foods, 2018, 40: 606-613.

5. Juanjuan Yang, Yindi Liu, Shuli Xu, Haiying Lin, Chun Meng, Donghai Lin*. Expression, puri?cation and characterization of the full-length SmpB protein from Mycobacterium tuberculosis. Protein expression and purification, 2018, 151: 9-17.

6. Juanjuan Yang, Lei Hu, Tiantian Cai, Qiuluan Chen, Qian Ma, Jie Yang, Chun Meng, Jing Hong*. Purification and identification of two novel antioxidant peptides from perilla (Perilla Frutescens L. Britton) seed protein hydrolysates. PLoS One, 2018, 13(7): 1-15.  

7. Lixian Mu, Lei Zhou, Juanjuan Yang, Li Zhuang, Jing Tang, Tong Liu, Jing Wu, Hailong Yang*. The first identified cathelicidin from tree frogs possesses anti?inflammatory and partial LPS neutralization activities. Amino Acids, 2017, 49: 1571-1585.

8. Juanjuan Yang, Yindi Liu, Zhao Liu, Chun Meng, Donghai Lin*. Backbone and side-chain resonance assignments for the tmRNA binding protein, SmpB, from Mycobacterium tuberculosis. Biomolecular NMR Assignments, 2017, 11(2): 175-179.

9. Juanjuan Yang, Yindi Liu, Jing Bi, Qixu Cai, Xinli Liao, Wenqian Li, Chenyun Guo, Qian Zhang, Tianwei Lin, Yufen Zhao, Honghai Wang, Jun Liu*, Xuelian Zhang*, Donghai Lin*. Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide. Molecular Microbiology, 2015, 95(5), 791-803. 

10. Lin Wei, Chunjing Huang, Hailong Yang, Min Li, Juanjuan Yang, Xue Qiao, Lixian Mu, Fei Xiong, Jing Wu*, Wei Xu*. A potent anti-inflammatory peptide from the salivary glands of horsefly. Parasit Vectors, 2015, 8: 556-556.

11. Lin Wei§, Juanjuan Yang^§, Xiaoqin He, Guoxiang Mo, Jing Hong, Xiuwen Yan*, Donghai Lin*, Ren Lai*. Structure and Function of a Potent Lipopolysaccharide-Binding Antimicrobial and Anti-inflammatory Peptide. J. Med.Chem. 2013, 56: 3546-3556(§, co-first author).

12.  Li Dong^§, JuanJuan Yang^§, Ying Wang, Huan Liu, LiXian Mu, Donghai Lin*, Ren Lai*. Structure-function  relationship  of  antimicrobial  peptide cathelicidin Pc-CATH1. Nat. Prod. Bioprospect., 2012, 2: 81–86 (§, co-first author).

13. Juanjuan Yang, Huicai Huang,  Zhichao Jin, Wenbin Wu, Jinxing Ye*. Diastereoselective Synthesis of Bicyclo[2.2.2]octan-2-one Derivatives through an Unexpected Organocatalytic Tandem Michael–Michael Reaction. Synthesis, 2011, 12: 1984-1987. 

14. Wenjun Li, Wenbin Wu, Juanjuan Yang, Xinmiao Liang, Jinxing Ye. As*, Asymmetric Direct Michael Addition of Acetophenone to α, β-Unsaturated Aldehyde. Synthesis, 2011, 7:1085-1091.

15. Juanjuan Yang, Wenjun Li, Zhichao Jin, Xinmiao Liang, Jinxing Ye*. Enantioselective  Michael  Reaction  of α-Alkyl-β-keto Esters and Enones under Multifunctional Catalysis. Org. Lett., 2010, 12: 5218-5221.

16. Chunlin Wu, Wenjun Li, Juanjuan Yang, Xinmiao Liang*, Jinxing Ye*. Asymmetric organocatalytic Michael addition of anthrone to enone, Org. Biomol. Chem., 2010, 8: 3244-3250.

專利申請：

1. 一種人源程序性死亡受體hPD-1單克隆抗體：楊娟娟，孟春，呂唯，劉照，吳茂，授權專利號 ZL 201611197005.3。

2. 一種人源程序性死亡因子配體hPD-L2單克隆抗體：楊娟娟，孟春，劉照，羅嶺，夏菁潞，徐淑麗授權專利號：2017102780143。

獲獎情況

1. 2018.11 福州大學生物科學與工程學院 青年教師“最佳一節課”教學競賽三等獎

2. 2017.11 指導全國大學生生命科學競賽 獲得三等獎

3. 2017.06 福州大學優秀本科畢業論文指導老師