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  • 生物科學與工程學院

    College of Biological Science and Engineering

    張龍斌

    發布日期:2022-02-25 發布者:

    姓名:張龍斌

    性別:男

    職稱:副研究員校聘

    學歷:理學博士

    QQ937351462

    電子郵箱:longbin_z@163.com

    研究方向:蛋白質與酶工程、基因調控、組學研究

    教育工作經歷:

    2020-至今 福州大學生物科學與工程學院       副研究員(校聘) / 福建省C類人才

    2016-2020    華僑大學醫學院                講師

    2011-2016    浙江大學                    微生物學博士

    2007-2011    福建師范大學                 生物技術學士

    承擔課程:

    1、 本科生:生物化學;有機化學;分子生物學;細胞生物學實驗

    2、 研究生:酶工程及其應用

    3、 校公選課:人類健康與現代醫學


    科研簡介:

    1、 微生物發酵產酶(漆酶、褐藻膠裂解酶等)及其工業化運用的研究;

    2、 微生物功能性代謝物(寡聚糖、羥基喹啉醌等)的生產與應用;

    3、 微生物組學的生物信息分析(轉錄組、代謝組、蛋白組、宏基因組等;

    4、 昆蟲病源真菌的基因功能及調控機理研究;


    社會兼職:

    轉化醫學雜志青年編委

    科研項目:

    1、 福建省自然科學基金面上項目:Sur7介導多代謝通路影響球孢白僵菌生防潛能的機制研究。(2021-2024年,10萬,主持)

    2、 福州大學人才項目:基于轉錄組與代謝組分析Sur7調控球孢白僵菌生長的分子機理。(2020-2022年,10萬,主持)

    3、 福州大學2022年貴重儀器設備開放測試基金:漆酶催化生物活性物質的聚合反應。(2022.1.1-2022.12.310.5萬,主持)

    4、 國家自然科學基金面上項目:多組學聯合解析BbRho4調控球孢白僵菌生長及抗氧化力的分子機制。(2021-2024年,69.6萬,參與)

    5、 國家自然科學基金青年項目MicroRNA對大腦皮層神經發生的反饋環路調控機制。(2018-2020年,20萬,主持)

    6、 福建省自然科學基金青年創新項目MicroRNA-26對大腦皮層神經發生的反饋環路調控機制。(2018-2021年,4萬,主持)

    代表性論文:(#共同第一作者;*為通訊作者)

    1. Zhang BL*, Qiu TT, Guan Y, Huang ZH, Ye XY. Analyses of transcriptomics and metabolomics reveal pathway of vacuolar Sur7 contributed to biocontrol potential of entomopathogenic Beauveria bassiana. J Invertebr Pathol. 2021. 181:107564. doi: 10.1016/j.jip.2021.107564. JCR 一區

    2. Zhang BL*, Qiu TT, Yang WWJ. Bioinformatic analysis reveals the distinct role of 5’UTR-specific m6A RNA modification in mice developing cerebral cortices. Dev Neurosci. 2022. doi: 10.1159/000521620. JCR 二區

    3. Zhang LB*, Qiu TT, Huang ZH, Ye XY, Guan Y*. Transcriptomic analysis of Sur7-mediated response of Beauveria bassiana to different nutritional conditions. FEMS Microbiol Lett. 2021. 368 (3): fnab003. JCR 三區

    4. Zhang LB, Tang L, Guan Y, Feng MG*. Subcellular localization of Sur7 and its pleiotropic effect on cell wall integrity, multiple stress responses, and virulence of Beauveria bassiana. Appl. Microbiol. Biotechnol. 2020. 104 (15): 6669-6678. JCR 二區

    5. Zhang LB, Du KZ, Wang J, Nie YZ, Lee T, Sun T*. Unique and specific m6A RNA methylation in mouse embryonic and postnatal cerebral cortices. Genes (Basel). 2020. 11 (10): E1139. JCR 二區

    6. Zhang LB, Feng MG*. Antioxidant enzymes and their contributions to biological control potential of fungal insect pathogens. Appl. Microbiol. Biotechnol. 2018. 102 (12): 4995-5004. (Review) JCR 二區

    7. Zhang LB, Tang L, Ying SH, Feng MG*. Two eisosome proteins play opposite roles in autophagic control and sustain cell integrity, function and pathogenicity in Beauveria bassiana. Environ Microbiol. 2017. 19 (5):2037-2052. JCR 一區

    8. Zhang LB#, Mubarak T#, Chen Y#, Lee T, Pollock A, Sun T*. Counter-balance between Gli3 and miR-7 is required for proper morphogenesis and size control of the mouse brain. Front. Cellular Neurosci. 2018. 12:259. JCR 二區

    9. Zhang LB, Tang L, Ying SH, Feng MG*. Distinct roles of cytoplasmic thioredoxin reductases (Trr1/Trr2) in the redox system involving cysteine synthesis and host infection of Beauveria bassiana. Appl. Microbiol. Biotechnol. 2016. 100 (24): 10363-10374.

    10. Zhang LB, Tang L, Ying SH, Feng MG*. Regulative roles of glutathione reductase and four glutaredoxins in glutathione redox, antioxidant activity, and iron homeostasis of Beauveria bassiana. Appl. Microbiol. Biotechnol. 2016. 100 (13): 5907-5917.

    11. Zhang LB, Tang L, Ying SH, Feng MG*. Subcellular localization of six thioredoxins and their antioxidant activity and contributions to biological control potential in Beauveria bassiana. Fungal Genet. Biol. 2014. 76: 1–9. JCR 二區

    12. Zhang HJ#, Zhang LB#, Sun T*. Cohesive regulation of neural progenitor development by microRNA miR-26, its host gene Ctdsp and target gene Emx2 in the mouse embryonic cerebral cortex. Front. Mol. Neurosci. 2018. 11: 44. JCR 二區

    13. Du KZ, Zhang LB, Sun T*. m6A RNA methylation controls neural development and is involved in human diseases. Mol. Neurobiol. 2018. 56 (3): 1596-1606. (高被引論文) JCR 一區

    14. Hussain G, Zhang LB, Rasul A, Anwar H, Sohail MU, Razzaq A, Aziz N, Shabbir A, Ali M, Sun T*. Role of plant-derived flavonoids and their mechanism in attenuation of Alzheimer’s and Parkinson’s Diseases: An update of recent data. Molecules. 2018. 23 (4): 814. JCR 二區

    15. Floris G, Zhang LB, Follesa P, Sun T*. Regulatory role of circular RNAs and neurological disorders. Mol Neurobiol. 2017. 24 (7): 5156-5165.

    16. Wang ZL, Zhang LB, Feng MG*. Catalases play differentiated roles in the adaptation of a fungal entomopathogen to environmental stresses. Environ. Microbiol. 2013. 15 (2): 409-418.

    17. Nie YZ, Tian GG, Zhang LB, Trevor L, Zhang Z, Li J, Sun T*. Identifying cortical specific long noncoding RNAs modified by m6A RNA methylation in mouse brains. Epigenetics. 2020. 23: 1-17.

    18. Zhang HJ., Chang YF, Zhang LB, Kim SN, Otaegi G, Zhang Z, Nie YZ, Mubarak T, Li C, Qin CF, Xu ZH, Sun T*. Upregulation of microRNA miR-9 is associated with microcephaly and Zika virus infection in mice. Mol Neurobiol. 2019.56 (6): 4072-4085.

    19. Li F, Wang ZL, Zhang LB, Ying SH, Feng MG*. The role of three calcineurin subunits and a related transcription factor (Crz1) in conidiation, multistress tolerance and virulence in Beauveria bassiana. Appl. Microbiol. Biotechnol. 2015. 99 (2): 827-840.


    獲獎情況:

    福州大學教學創新大賽 一等獎;


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