職務：副研究員/碩士生導師

學歷：博士

電子郵件： zdluoman1987@163.com

主要研究方向：腫瘤新抗原/溶瘤免疫治療、放療與免疫治療、納米光學診療

教育工作經歷：

1.2006/9–2010/7，吉林農業大學，生物技術，學士

2.2010/9–2013/12，華南師范大學，生物物理學，碩士

3.2013/7–2016/9，福建醫科大學孟超肝膽醫院，研究員實習員

4.2016/9–2020/8，福建醫科大學孟超肝膽醫院，助理研究員員

5.2017/9–2020/12，福州大學，分析化學，博士

6. 2021/1–至今，福州大學孟超醫學與交叉科學中心，副研究員

7.2021/1–至今，福建醫科大學孟超肝膽醫院，副研究員

教學簡介：

無

科研簡介：主要從事光學診療納米制劑、放療增敏劑、超分子藥物配位自主組、納米疫苗及溶瘤病/NK等靶向遞送與免疫治療研究。已在Nano Letters, Angewandte Chemie, ACS Nano, Advanced Science, Small, iScience, Chemical Engineering Journal, Theranostics, Chemical Science, ACS applied materials & interfaces及科學通報等期刊發表SCI論文30篇，ESI高引論文3篇，公開國家發明專利11項（授權6項，第一發明人4項），PCT專利1項； 2021年入選福建省高層次人才（C類）；2022年獲福建省杰出青年項目資助；主持國自然基金青年項目1項，參與國家及重點項目等4項；主持福建省科技創新聯合資金及面上、杰青項目等4項；主持福建省中青年骨干項目1項；

社會兼職：中國抗癌協會抗癌藥物專業委員會青年委員（2020），《ACS Nano》、《Advanced Science》、《Small》、《Chemical Engineering Journal》、《ACS applied materials & interfaces》，《Biomaterials》、《Acta biaomaterials》等雜志審稿人。

科研項目：

1. 2019.01---2021.12，國家自然科學基金青年項目：智能核殼型金屬有機配位聚合物用于磁共振引導的腫瘤近紅外二區光熱協同治療(61805041)，25萬元，主持，結題；

2. 2022.08.01---2025.08.01福建省自然科學基金杰青項目：新生抗原疫苗遞送載體設計及其應用，2022J06034，30萬，主持，在研；

3. 2022.10-2025.10，福建省科技創新聯合資金項目：新型放療增敏納米材料提高腫瘤放射治療效應的研究（交叉學科項目）, 2021Y9216，200萬，主持，在研；

4. 2022.08---2024.08福建省衛健委中青年骨干項目：新生抗原疫苗胞質遞送增強肝癌個性化免疫治療，2021GGB020，5萬，主持，在研；

5. 2020.11---2023.11，福建省自然科學基金面上項目：基于光敏配位聚合物調控腫瘤微環境增強肝癌光化學-免疫治療研究(2020J011154)，7萬元，主持，在研；

6. 2016/04-2019/04，福建省自然科學基金面上項目：還原性敏感光敏化DNA-AQ4N適配體用于靶向肝癌監測及光動力誘導乏氧性化療聯合治療(2016J01174)，4萬元，主持，結題；

7.  2015/04-2018/03，福州市科技計劃項目：半導體聚合物納米膠束用于肝癌光聲-核磁共振成像及光學協同治療的研究(2015-S-143-11)，5萬元，主持，結題；

8.  2014/07-2017/06，福州市衛生系統科技計劃項目：Gd/Au雜化脂質體作為肝癌靶向的CT/MRI雙模態影像及熱療探針的應用研究(2014-S-w25)，4萬元，主持，結題；

9.  2016/01-2019/12，國家自然科學基金面上項目： 腫瘤特異靶向的長循環多功能納米膠束用于肝癌的光聲成像及光熱/光動力協同治療研究(61575044)，60萬元，參與，結題；

10.  2016/01-2019/12，國家自然科學基金“促進海峽兩岸科技合作聯合基金”：光聲/MRI/CT多模態成像監測原發性肝癌靶向微創治療(U1505221)，215萬元，參與，結題；

11.  2018/01-2022/12，國家自然科學基金“國家重大科研儀器研制項目”：基于波前整形的高光譜成像引導的腫瘤光熱/光動力雙模治療手術系統(61727823)，780萬元，參與，在研；

12.  2020/01-2023/12, 國家自然科學基金重大研究計劃“基于核酸適體的膀胱癌相關標志物發現和可視化分析(91959102)”80萬，參與，在研；

已發表論文：（*為通訊作者）

(1) Da Zhang*#, Chenwei Jiang#, Xiaoyuan Zheng#, Zhiwen Lin#, Qiuyu Zhuang, Huanzhang Xie, Yuzhi Liang, Yu Xu, Linsheng Cui, Xiaolong Liu*, Yongyi Zeng*. Normalization of Tumor Vessels by Lenvatinib-Based Metallo-Nanodrugs Alleviates Hypoxia and Enhances Calreticulin-Mediated Immune Responses in Orthotopic HCC and Organoids. Small (2023): 2207786 (IF: 15.153, 一區)

(2) Ming Wu#, Hao Li#, Cao Zhang, Yingchao Wang, Cuilin Zhang, Yuting Zhang, Aoxue Zhong, Da Zhang*, Xiaolong Liu*. Silk-Gel Powered Adenoviral Vector Enables Robust Genome Editing of PD-L1 to Augment Immunotherapy across Multiple Tumor Models. Advanced Science (2023): 2206399. (IF: 17.521, 一區)

(3) Qingfu Zhao#, Yunhao Wang#, Binyu Zhao#, Hengkai Chen, Zhixiong Cai, Youshi Zheng, Yongyi Zeng, Da Zhang*, and Xiaolong Liu* Neoantigen Immunotherapeutic-Gel Combined with TIM-3 Blockade Effectively Restrains Orthotopic Hepatocellular Carcinoma Progression. Nano Lett. 2022. 9;22(5):2048-2058. (IF: 11.189, 一區, TOP)

(4) [2] Yunhao Wang#, Qingfu Zhao#, Binyu Zhao, Youshi Zheng, Qiuyu Zhuang, Naishun Liao, Peiyuan Wang, Zhixiong Cai, Da Zhang*, Yongyi Zeng*, Xiaolong Liu*. Remodeling Tumor-Associated Neutrophils to Enhance Dendritic Cell-Based HCC Neoantigen Nano-Vaccine E?ciency. Advanced Science. 2022, 2105631. (IF: 17.521, 一區)

(5) Zhijin Fan, Cheng Jiang, Yichao Wang, Kaiyuan Wang, Jade Marsh, Da Zhang*, Xin Chen*, Liming Nie* Engineered Extracellular Vesicles as Intelligent Nanosystem for Next-Generation of Nanomedicine, Nanoscale Horiz, 2022,7, 682-714. (IF: 11.684, 一區)

(6) [Da Zhang#, Tianhong Teng#, Qingfu Zhao#, Zhiwen Lin, Junrong Zhang, Xiaolong Liu, and Yongyi Zeng* Nanoparticles for Near-Infrared Light-Driven Singlet Oxygen and CO Gas Cogeneration for Pancreatic Adenocarcinoma Therapy, ACS Appl. Nano Mater. 2022, 5, 11, 16741–16752 (IF: 6.1, 二區)

(7) Da Zhang#, Youshi Zheng#, Ziguo Lin, Xiaolong Liu, Juan Li*, Huanghao Yang*, Weihong Tan. Equipping Natural Killer Cells with Specific Targeting and Checkpoint Blocking for Enhanced Adoptive Immunotherapy in Solid Tumors. Angew Chem Int Ed Engl.2020.59,12022-12028. (IF: 16.823, 一區, TOP)

(8) Da Zhang#, Ziguo Lin#, Ming Wu#, Zhixiong Cai, Youshi Zheng, Lei He, Zhenli Li, Jie Zhou, Liqin Sun, Geng Chen, Yongyi Zeng, Juan Li, Jingfeng Liu*, Huanghao Yang*, Xiaolong Liu*.Cytosolic Delivery of Thiolated Neoantigen Nano-vaccine Combined with Immune Checkpoint Blockade to Boost Anti-cancer T Cell Immunity. Advanced Science. 2021. 8, 2003504. (IF: 17.521, 一區)

(9) Da Zhang#, Ziguo Lin#, Youshi Zheng, Jibin Song, Juan Li, Yongyi Zeng,* and Xiaolong Liu*. Ultrasound-Driven Biomimetic Nanosystem Suppresses Tumor Growth and Metastasis through Sonodynamic Therapy, CO Therapy, and Indoleamine 2,3-Dioxygenase Inhibition. ACS Nano, 2020. 14, 8985-8999. (IF: 18.027, 一區)

(10) Chengyun Chen, Yuhong Tong, Youshi Zheng, Yingjun Shi, Zhaowei Chen, Juan Li, Xiaolong Liu, Da Zhang*, Huanghao Yang*. Cytosolic Delivery of Thiolated Mn-cGAMP Nanovaccine to Enhance the Antitumor Immune Responses. Small. 2021.2006970. (IF: 15.153, 一區)

(11) Xianglian Liao, Youshi Zheng, Ziguo Lin, Yi Shen, Huiyun Lin, Xiaolong Liu, Da Zhang*, Buhong Li*. Self-assembled metallo-supramolecular nanoflowers for NIR / acidic-triggered multidrug release, long-term tumor retention and NIR-II fluorescence imaging-guided photo-chemotherapy. Chemical Engineering Journal. 2020. 400, 125882. (IF: 16.8, 一區)

(12) Da Zhang#, Youshi Zheng#, Ziguo Lin, Shanyou Lan, Xiaolong Zhang, Aixian Zheng, Juan Li, Gang Liu, Huanghao Yang, Xiaolong Liu*, Jingfeng Liu*. Artificial Engineered Natural Killer Cells Combined with Antiheat Endurance as Powerful Strategy for Enhancing Photothermal- Immunotherapy Efficiency of Solid Tumors. Small. 2019. 15, 1970228. (IF: 15.153, 一區)

(13) Da Zhang# , Cuilin Zhang# , Shanyou Lan, Yanbing Huang, Jingfeng Liu, Juan Li*, Xiaolong Liu*, Huanghao Yang* Near-Infrared Light Activated Thermosensitive Ion Channel to Remotely Control Transgene System for Thrombolysis Therapy. Small. 2019. 15, 1901176. (IF: 15.153, 一區)

(14) Da Zhang#, Ming. Wu, Zhixiong Cai, Naishun Liao, Kun Ke, Hongzhi Liu, Ming Li, Gang Liu, Huanghao Yang, Xiaolong Liu* , Jingfeng Liu*. Chemotherapeutic Drug Based Metal–Organic Particles for Microvesicle-Mediated Deep Penetration and Programmable pH/NIR/Hypoxia Activated Cancer Photochemotherapy. Advanced Science, 2018. 5, 1700648. (IF: 17.521, 一區)

(15) Da Zhang, Aixian Zheng, Juan Li, Ming Wu, Zhixiong Cai, Lingjie Wu, Zuwu Wei, Huanghao Yang, Gang Liu, Xiaolong Liu* , Jingfeng Liu*. Tumor Microenvironment Activable Self-Assembled DNA Hybrids for pH and Redox Dual-Responsive Chemotherapy / PDT Treatment of Hepatocellular Carcinoma, Advanced Science, 2017. 4, 1600460. (IF: 17.521, 一區)

(16) Da Zhang, Aixian Zheng, Juan Li, Ming Wu, Lingjie Wu, Zuwu Wei, Naishun Liao, Xiaolong Zhang, Zhixiong Cai, Huanghao Yang, Gang Liu, Xiaolong Liu* , Jingfeng Liu*.Smart Cu(II)-aptamer complexes based gold nanoplatform for tumor micro-environment triggered programmable intracellular prodrug release, photodynamic treatment and aggregation induced photothermal therapy of hepatocellular carcinoma. Theranostics, 2017, 7,164-179. (IF: 11.556, 一區)

(17) Da Zhang, Zhixiong Cai, Naishun Liao, Shanyou Lan, Ming Wu, Haiyan Sun, Zuwu Wei,Juan Li*, Xiaolong Liu*.pH / hypoxia programmable triggered cancer photo-chemotherapy based on a semiconducting polymer dot hybridized mesoporous silica framework. Chemical science, 2018. 9, 7390-7399. (IF: 9.825, 一區)

(18) [Ming Wu#, Dongye Zheng#, Da Zhang #, Peiwen Yu, Lianli Peng, Feng Chen, Ziguo Lin,Zhixiong Cai, Jiong Li, Zuwu Wei, Xinyi Lin, Jingfeng Liu*, Xiaolong Liu*. Converting Immune Cold into Hot by Biosynthetic Functional Vesicles to Boost Systematic Antitumor Immunity. iScience, 2020. 23, 101341. (IF: 6.4, 二區)

(19) Da Zhang, Ming Wu., Yongyi Zeng, Lingjie Wu, Qingtang Wang, Xiao Han, Xiaolong Liu*, Jingfeng Liu*.Chlorin e6 conjugated poly (dopamine) nanospheres as PDT / PTT dual-modal therapeutic agents for enhanced cancer therapy, ACS applied materials & interfaces, 2015. 7, 8176- 8187. (IF: 10.383, 二區)

(20) Da Zhang, Hao Xu, Xiaolong Zhang, Yubin Liu, Ming Wu, Juan Li, Huanghao Yang, Gang Liu, Xiaolong Liu*, Jingfeng Liu*, Zhen Yuan. Self-Quenched Metal-Organic Particles as Dual-Mode Therapeutic Agents for Photoacoustic Imaging-Guided Second Near-Infrared Window Photochemotherapy. ACS applied materials & interfaces, 2018. 10, 25203-25212. (IF: 10.383, 二區)

(21) Shanyou Lan, Ziguo Lin, Da Zhang*, Yongyi Zeng*, Xiaolong Liu.  Photocatalysis Enhancement for Programmable Killing of Hepatocellular Carcinoma through Self-Compensation Mechanisms based on Black Phosphorus Quantum Dot hybridized Nanocatalysts, ACS applied materials & interfaces, 2019. 11, 9804-9813. (IF: 10.383, 二區)

(22) Yanlin Du#, Da Zhang#, Yiru Wang, Ming Wu, Cuilin Zhang, Youshi Zheng, Aixian Zheng*, Xiaolong Liu*. A highly stable multifunctional aptamer for enhancing antitumor immunity against hepatocellular carcinoma by blocking dual immune checkpoints Biomaterials Science. 2021. 9, 4159-4168. (IF: 7.590, 二區)

(23) Youshi. Zheng, Cuilin. Zhang, Zishen. Lai, Yongyi. Zeng, Juan. Li, Da. Zhang* and Xiaolong. Liu*, Redirecting natural killer cells to potentiate adoptive immunotherapy in solid tumors through stabilized Y-type bispecifific aptamer. Nanoscale, 2021.13,11279. (IF: 8.307, 二區)

(24) Liao, Naishun#, Da Zhang#, Ming Wu, Huanghao Yang, Xiaolong Liu*, and Jibin Song*. Enhancing therapeutic effects and in vivo tracking of adipose tissue-derived mesenchymal stem cells for liver injury using bioorthogonal click chemistry. Nanoscale. 2021.13,1813-1822. (IF: 8.307, 二區)

(25) Tianhong Teng#, Ronggui Lin#, Ziguo Lin, Kun Ke, Xianchao Lin, Maoen Pan, Da Zhang*, Heguang Huang*, Photothermal augment stromal disrupting effects for enhanced Abraxane synergy chemotherapy in pancreatic cancer PDX mode. Biomaterials Science. 2020. 21, 8: 3278-3285. (IF: 7.590, 二區)

(26) Da Zhang#, Ziguo Lin#, Shanyou Lan, Haiyan Sun*, Yongyi Zeng* Xiaolong Liu*. The Design of Janus Black Phosphorus Quantum dots@Metal-Organic Nanoparticles for Simultaneously Enhancing Environmental Stability and Photodynamic therapy Efficiency, Mater. Chem. Front., 2019, 3, 656-663. (IF: 8.4, 二區)

(27) Da Zhang # , Xiao Lin# , Shanyou Lan# , Haiyan Sun, Xuandong Wang, Xiaolong Liu, Yun Zhang, and Yongyi Zeng*.  Localized Surface Plasmon Resonance Enhanced Singlet Oxygen Generation and Light Absorption Based on Black Phosphorus@AuNPs Nanosheet for Tumor Photodynamic / Thermal Therapy. Particle&Particle Systems Characterization, 2018. 35, 1800010. (IF: 3.31, 三區)

(28) Da Zhang, Ming Wu, Yongyi Zeng, Naishun Liao, Zhixiong Cai, Gang Liu, Xiaolong Liu*, Jingfeng Liu*.Lipid micelles packaged with semiconducting polymer dots as simultaneous MRI / photoacoustic imaging and photodynamic / photothermal dual-modal therapeutic agents for liver cancer. Journal of Materials Chemistry B, 2016. 4, 589-599. (IF: 6.331, 二區)

(29) Zhixiong Cai#, Da Zhang#, Xinyi Lin, Yunzhu Chen, Ming Wu, Zuwu Wei, Zhenxi Zhang1, Xiaolong Liu5,2,3 and Cuiping Yao5,1 (2017). Glutathione responsive micelles incorporated with semiconducting polymer dots and doxorubicin for cancer photothermal-chemotherapy. Nanotechnology, 28(42), 425102.

(30) 張達, 周非凡, 邢達. 功能化氧化石墨烯的靶向腫瘤成像與光熱治療. 科學通報, 2013; 7: 586-592.11

授權發明專利：

(1) 張達;劉景豐;劉小龍;吳名,一種PEG修飾的二維納米片光熱轉換材料及其應用.專利號ZL 201710655253.6；

(2) 張達;劉小龍;吳名;劉景豐,腫瘤微酸性敏感的銅-藥物共配位自組裝納米粒及應用.專利號ZL 201710102120.6；

(3) 張達;劉景豐;劉小龍;曾永毅,一種光敏納米復合物及其制備方法和應用.專利號ZL 201811343150.7；

(4) 張達;曾永毅;劉景豐;劉小龍,黑磷量子點/鉑雜化介孔二氧化硅納米顆粒及制備方法和應用.專利號ZL 201811343125.9；

(5) 劉景豐;劉小龍;黃愛民; 張達, 用于肝癌多模態影像和光熱治療的多功能納米探針及應用.專利號ZL 201310695697.4；

(6) 劉小龍;劉景豐; 張達;曾永毅, 用于腫瘤早期診斷與光學治療的多功能納米膠束及其應用. 專利號ZL 201510429203.7；（已轉化，金額120萬元,見附件）；

(7) 劉小龍; 張達;鄭友世;蔡志雄;蘇小平.一種人工改造自然殺傷性細胞及其制備與應用.專利號201910324655.7；

(8) 楊黃浩;李娟; 張達;劉小龍, 含有至少2個硫原子的雜環化合物在制備納米疫苗中的應用及制得的納米疫苗.專利號202010330996.8；

(9) 鄭友世;劉小龍; 張達;林自國. 一種核酸適體功能化NK細胞及其制備與應用.專利號202010530479.5；

(10) 劉景豐;劉小龍;鄭友世; 張達;曾永毅.一種增強NK細胞對腫瘤細胞靶向殺傷力的培養方法.專利號202010353458.0；

(11) 吳名; 張達;劉小龍;劉景豐;曾永毅.用于聲動力/氣體協同抗腫瘤治療的仿生納米材料及其制備方法.專利號202010555452.1；

(12) 楊黃浩;李娟;張達;劉小龍.APPLICATION OF HETEROCYCLIC COMPOUND CONTAINING AT LEAST TWO SULFUR ATOMS IN PREPARING NANO-VACCINE AND PREPARED NANO-VACCINE. PCT/CN2020 / 134162.

獲獎情況

2022年福建自然科學優秀學術論文一等獎;

2022年福州市自然科學優秀學術論文一等獎;

2021年福建省科學技術進步獎一等獎（4/10）;

2020年福建醫學科技獎二等獎（4/7）；

2020年醫學科技突出貢獻工作者；

2014年福州市十佳創新能手；