教育工作經歷：

2026.01~至今，福州大學，生物科學與工程學院，講師

2023.07~2025.11，浙江大學，生物系統工程與食品科學學院，農業工程，博士后/助理研究員

2018.09~2023.06，浙江大學，生物系統工程與食品科學學院，食品科學，博士（碩博連讀）

2014.09~2018.06，海南大學，食品學院，食品質量與安全，學士

教學簡介：無

本科生課程：福州大學至誠學院《營養學》、《食品化學》

研究生課程：福州大學《食品分子生物學》

科研簡介：

主要研究方向為（1）食品漿果來源花色苷類多酚（如矢車菊素-3-O-葡萄糖苷）的抗氧化、抗炎與糖脂代謝調控活性及其分子機制；（2）漿果花色苷對食品污染物微塑料誘導的腸道菌群失調、代謝紊亂、結腸炎等毒性的干預作用及機制；（3）牛乳、蜂王漿、梔子等來源外泌體的提取、生物活性及其靶向遞送應用等。合計發表SCI論文34篇，其中以第一或通訊作者（含共同）在Journal of Agricultural and Food Chemistry、Journal of Hazardous Materials、Materials Today Bio、Food & Function等期刊發表論文12篇，總引用數780余次，個人H-指數18。主持中國博士后科學基金面上項目1項，參與國家自然科學基金面上項目1項；申請國家發明專利3項（1項已授權）。

社會兼職：

（1）擔任Frontier in Cellular and Infection Microbiology（IF=4.9，中科院2區）期刊，專刊客座主編；

（2）擔任Journal of Hazardous Materials、Food Research International、LWT-Food Science and Technology、Food Bioscience、The Journal of Nutritional Biochemistry等期刊審稿人。

主持科研項目：

（1）福州大學引進人才啟動項目（2026-2028，主持）

（2）中國博士后科學基金第76批面上項目（2024.11-2025.11，主持）

（3）杭州市博士后科研啟動項目（2023.7-2025.11，主持）

代表性論文：

[1] Wu Yuanjie#, Chen Wen #,*, Ye Xiang, Hao Xingkai, Wen Yuhao, Wu Jian, Li Danyang, and Xu Lizhou*. Targeted C3G delivery by engineered milk exosomes for effective therapy in microplastics-induced colitis. Materials Today Bio, 2026, 36, 102639.

[2] Chen Wen, Wang Haobo, Ye Xiang, Hao Xingkai, Yan Fujie, Wu Jian, Li Danyang, Wang Yan* & Xu Lizhou*. Gardenia-derived extracellular vesicles exert therapeutic effects on dopaminergic neuron apoptosis-mediated Parkinson's disease. npj Parkinson's Disease, 2025, 11(1), 200.

[3] Chen Wen, Zheng Xiaodong, Yan Fujie, Xu Lizhou* & Ye Xiang*. Modulation of Gut Microbial Metabolism by Cyanidin-3-O-Glucoside in Mitigating Polystyrene-Induced Colonic Inflammation: Insights from 16S rRNA sequencing and Metabolomics. Journal of Agricultural and Food Chemistry, 2024, 72(13),7140–7154.

[4] Ye Xiang#, Chen Wen#, Huang Xufan, Yan Fujie, Deng Shuiguang & Zheng Xiaodong*, Shan Pengfei*. Anti-diabetic effect of anthocyanin cyanidin-3-O-glucoside: data from insulin resistant hepatocyte and diabetic mouse. Nutrition & Diabetes, 2024, 14(1), 7.

[5] Chen Wen, Zhu Ruiyu, Ye Xiang, Sun Yunhao, Tang Qiong, Liu Yangyang, Yan Fujie, Yu Ting, Zheng Xiaodong, Tu Pengcheng*. Food-derived cyanidin-3-O-glucoside reverses microplastic toxicity via promoting discharge and modulating the gut microbiota in mice. Food & Function, 2022, 13, 1447.

[6] Ye Xiang#, Wen Chen#, Tu Pengcheng, Jia Ruoyi, Liu Yangyang, Tang Qiong, Chen Chuan, Yang Caihong, Zheng Xiaodong*. Antihyperglycemic effect of an anthocyanin, cyanidin-3-O-glucoside, is achieved by regulating GLUT-1 via Wnt/β-catenin-WISP1 signaling pathway. Food & Function, 2022, 13, 4612–4623.

[7] Chen Wen, Ye Xiang, Tang Qiong, Yu Ting, Pengcheng Tu* & Zheng Xiaodong*. Cyanidin-3-O-glucoside reduces nanopolystyrene-induced toxicity and accumulation: roles of mitochondrial energy metabolism and cellular efflux. Environmental Science: Nano, 2022, 9, 2572.

[8] Chen Wen#, Chen Zhen#, Shan Shuo, Wu Aibo, Zhao Chao, Ye Xiang, Zheng Xiaodong & Zhu Ruiyu*. Cyanidin-3-O-glucoside promotes stress tolerance and lifespan extension of Caenorhabditis elegans exposed to polystyrene via DAF-16 pathway. Mechanisms of Ageing and Development, 2022, 207, 111723.

[9] Chen Wen, Tu Pengcheng, Ye Xiang, Tang Qiong, Yu Ting & Zheng Xiaodong*. Cyanidin-3-O-glucoside impacts fecal discharge of polystyrene microplastics in mice: Potential role of microbiota-derived metabolites. Toxicology and Applied Pharmacology, 2022, 453, 116212.

[10] Chen Wen#, Chu Qiang#, Ye Xiang, Sun Yuhao, Liu Yangyang, Jia Ruoyi, Li Yonglu, Tu Pengcheng, Tang Qiong, Yu Ting, Chen Chuan, Zheng Xiaodong*. Canidin-3-glucoside prevents nano-plastics induced toxicity via activating autophagy and promoting discharge. Environmental Pollution, 2021, 274, 116524.

[11] Chu Qiang# , Chen Wen# , Jia Ruoyi, Ye Xiang, Li Yonglu, Liu Yangyang, Jiang Yong, Zheng Xiaodong*. Tetrastigma hemsleyanum leaves extract against acrylamide-induced toxicity in HepG2 cells and Caenorhabditis elegans. Journal of Hazardous Materials, 2020, 393, 122364.

[12] 陳文, 朱莉婭, 韓宇, 劉東莉*. 表面增強拉曼光譜技術應用于西瓜中殺螟硫磷農藥殘留的檢測. 食品科技, 2018,43(01):320-325.

授權專利情況：

[1] 梔子源細胞外囊泡在制備防治神經退行性疾病藥物中的應用. 2025, 專利號：ZL 2024 11248476.7

[2] miRNA、包括其的miRNA組合產品及應用. 2025, 申請號: 202510570024.9

[3] 一種乳房炎miRNA標志物的傳感檢測用試劑盒、傳感檢測方法. 2025, 申請號: 202511877122.3

獲獎情況：

[1] 2025中國商業聯合會科技進步二等獎（參與）

[2] 浙江大學優秀畢業研究生

[3] 浙江大學啟真獎學金、康而達獎學金

[4] 國家留學基金委公派出國留學資格（CSC）

[5] 海南大學優秀畢業生

[6] 國家獎學金