教育工作經歷:
1. 2019.6-至今 福州大學,副教授
2. 2016.8-2019.6 福州大學,講師
3. 2011.8-2016.6 浙江大學,微生物學,博士
4. 2007.9-2011.6 福建農林大學,生物技術,學士
承擔課程:
微生物學、基因工程、微生物工程、微生物學實驗、細胞生物學實驗、綜合實驗課、酶工程及其應用(碩士研究生課程)
科研簡介:
結合基因編輯、異源表達等分子生物學手段及微生物代謝組、轉錄組等組學分析技術,開展昆蟲病原真菌基因功能、植物病原細菌抗生素耐藥性等相關方向的研究
社會兼職:
1.中國生物化學與分子生物學會農業生物化學與分子生物學分會,青年委員
2.福建省細胞生物學與轉化醫學學會,理事會理事
科研項目:
1. 國家自然科學基金面上項目:多組學聯合解析BbRho4調控球孢白僵菌生長及抗氧化力的分子機制,2020.01-2024.12,主持
2. 國家自然科學基金青年項目:Rho家族GTPase對球孢白僵菌極性生長及抗氧化力的作用研究,2018.01-2020.12,主持
3. 福建省自然科學基金青年創新項目:小GTP酶Rho4對球孢白僵菌生長、抗逆的作用研究,2018.04-2021.03,主持
4. 福建省教育廳一般項目:柑橘類水果皮中產果膠酶菌株的篩選及鑒定,2017.07-2020.06,主持
5. 福州市科技局科技計劃項目:果膠酶的發酵生產及其在動物飼料中的應用,2017.03-2019.03,主持
6. 福州大學貴重儀器設備開放測試基金:代謝組學在水稻黃單胞菌抗藥性形成機制中研究中的應用,2019.01-2019.12,主持
近年代表性論文:(*為通訊作者)
Guan, Y.*, Lin, M., Shen, P. & Zou, Z. (2023) Alanine-mediated P cycle boosting enhances the killing efficiency of kasugamycin on antibiotic-resistant Xanthomonas oryzae, Frontiers in Microbiology. 14:1160702
Zou, Z., Lin, M., Shen, P. & Guan, Y*. (2023) Alanine-Dependent TCA Cycle Promotion Restores the Zhongshengmycin-Susceptibility in Xanthomonas oryzae, International Journal of Molecular Sciences. 24.
Guan, Y.*, Wang, D., Lin, X., Li, X., Lv, C., Wang, D. & Zhang, L*. (2022) Unveiling a Novel Role of Cdc42 in Pyruvate Metabolism Pathway to Mediate Insecticidal Activity of Beauveria bassiana, Journal of fungi. 8.
Guan, Y.*, Shen, P., Lin, M. & Ye, X*. (2022) Exogenous Alanine Reverses the Bacterial Resistance to Zhongshengmycin with the Promotion of the P Cycle in Xanthomonas oryzae, Antibiotics. 11.
Zhang, L.*, Qiu, T., Huang, Z., Ye, X. & Guan, Y.* (2021) Transcriptomic analysis of Sur7-mediated response of Beauveria bassiana to different nutritional conditions, FEMS microbiology letters. 368.
Wang, Q., Lin, M., Shen, P. & Guan, Y.* (2021) Elevation of Fatty Acid Biosynthesis Metabolism Contributes to Zhongshengmycin Resistance in Xanthomonas oryzae, Antibiotics. 10.
Guan, Y., Wang, Q., Lv, C., Wang, D. & Ye, X.* (2021) Fermentation time-dependent pectinase activity is associated with metabolomics variation in Bacillus licheniformis DY2, Process Biochemistry. 101, 147-155.
Guan, Y., Wang, D., Lv, C., Zhang, Y., Gelbic, I.* & Ye, X.* (2020) Archives of microbiology: screening of pectinase-producing bacteria from citrus peel and characterization of a recombinant pectate lyase with applied potential, Archives of microbiology. 202, 1005-1013.
Du, X., Wang, D., Yin, D., Guan, Y.* & Ye, X.* (2019) Exogenous Glucose Promotes Growth and Pectinase Activity of Bacillus licheniformis DY2 Through Frustrating the TCA Cycle, Biotechnology and Bioprocess Engineering. 24, 942-953.
Guan, Y.*, Yin, D., Du, X. & Ye, X.* (2018) Metabolomics approach used for understanding temperature-related pectinase activity in Bacillus licheniformis DY2, FEMS microbiology letters. 365.
Guan, Y.*, Yin, D., Du, X. & Ye, X.* (2018) Functional metabolomics approach reveals the reduced biosynthesis of fatty acids and TCA cycle is required for pectinase activity in Bacillus licheniformis, J Ind Microbiol Biotechnol. 45, 951-960.
獲獎情況:
1. 2019.6 福州大學優秀本科生畢業論文指導教師
2. 2018.12 福州大學“三下鄉”社會實踐先進工作者
其他: