教育工作經歷：

2025.10 至 今：福州大學 | 生物科學與工程學院 | 副研究員/碩士生導師

2025.09 至 2025.10：福州大學 | 生物科學與工程學院 | 講師

2020.09 至 2025.06：浙江大學 | 化學工程與技術 | 博士

2023.11 至 2024.10：意大利米蘭理工大學 | 化學工程 | 聯合培養

2023.04 至 2023.09：奧地利維也納自然資源與生命科學大學 | 生物技術 | 聯合培養

2016.09 至 2020.06：廈門大學 | 生物工程 | 學士

科研簡介：

圍繞生物分離過程開展建模與優化研究，以第一作者在Biotechnol Bioeng，J Chromatogr A等期刊發表SCI論文12篇，參編圖書著作1章，獲軟件著作權4項，擔任SCI期刊Processes客座編輯及多個國際知名期刊審稿人。

主要研究方向概括如下：

[1] AI賦能生物分離過程建模與優化：引入機器學習與深度學習技術，開發機理與數據融合驅動的建模方法，輔助層析、過濾等生物分離下游工藝的過程優化。

[2] 連續生物制藥與新型分離技術：聚焦單克隆抗體、小核酸、多肽等生物藥物，探索連續流層析等新型工藝，促進生物制藥過程的連續化與高效化。

歡迎具有生物、化工、制藥、計算機背景，對“AI+生物制藥”交叉領域感興趣的同學加入！

更多個人信息與研究進展，歡迎訪問：www.chen-group.cn

主持科研項目：

[1] 福建省自然科學基金-創青項目

[2] 福州大學科技基金-引進人才科研啟動項目

[3] 生物質化工教育部重點實驗室開放課題

[4] 福州大學福建省高校測試中心貴重儀器設備開放測試基金

代表性論文：

[1] Chen Yu-Cheng, Fioretti Ismaele, Lin Dong-Qiang, Sponchioni Mattia*. Hybrid modeling of the reversed-phase chromatographic purification of an oligonucleotide: Few-shot learning from differentiable physics solver-in-the-loop [J]. Biotechnology and Bioengineering, 2025, 122(8): 2179–2192. (福州大學國際頂級期刊)

[2] Chen Yu-Cheng, Recanati Gabriele, De Mathia Fernando, Lin Dong-Qiang, Jungbauer Alois*. Residence time distribution in continuous virus filtration [J]. Biotechnology and Bioengineering, 2024, 121(6): 1876–1888. (福州大學國際頂級期刊)

[3] Chen Yu-Cheng, Yao Shan-Jing, Lin Dong-Qiang*. Integrating order-of-magnitude analysis to physics-informed neural networks for linear chromatographic models [J]. Industrial & Engineering Chemistry Research, 2025, 64(6): 3168–3182.

[4] Chen Yu-Cheng, Zhong Xue-Zhao, Shi Ce, Chen Ran, Sponchioni Mattia, Yao Shan-Jing, Lin Dong-Qiang*. Mechanistic modeling of anti-Langmuirian to Langmuirian behavior of Fc-fusion proteins in cation exchange chromatography [J]. Journal of Chromatography A, 2025, 1741: 465602.

[5] Chen Yu-Cheng, Yao Shan-Jing, Lin Dong-Qiang*. Enhancing thermodynamic consistency: Clarification on the application of asymmetric activity model in multi-component chromatographic separation [J]. Journal of Chromatography A, 2024, 1731: 465156.

[6] Chen Yu-Cheng, Yao Shan-Jing, Lin Dong-Qiang*. Parameter-by-parameter method for steric mass action model of ion exchange chromatography: Simplified estimation for steric shielding factor [J]. Journal of Chromatography A, 2023, 1687: 463655.

[7] Chen Yu-Cheng, Yao Shan-Jing, Lin Dong-Qiang*. Parameter-by-parameter method for steric mass action model of ion exchange chromatography: Theoretical considerations and experimental verification [J]. Journal of Chromatography A, 2022, 1680: 463418.

[8] Chen Yu-Cheng, Chen Zhiyuan, Dai Shi-Peng, Xie Youping, Yao Shan-Jing, Lin Dong-Qiang*. Evolution of chromatographic modeling: From mechanistic models to hybrid models with physics-based deep learning [J]. Journal of Chromatography A, 2026, 1765: 466565.

[9] Chen Yucheng, Qiu Zehao, Zhang Wen, Huang Xinxin, Ma Ruijuan, Wang Baobei, Ho Shih-Hsin, Chen Jianfeng, Xie Youping*. Hyperproduction of lutein and protein in a novel yellow mutant of chlorella sorokiniana via modulation of carbon?nitrogen metabolism under high-cell-density heterotrophic cultivation [J]. Algal Research, 2026, 95: 104626.

[10] Chen Yu-Cheng, Lu Hui-Li, Wang Rong-Zhu, Sun Guo, Zhang Xue-Qin, Liang Jing-Qi, Jungbauer Alois, Yao Shan-Jing, Lin Dong-Qiang*. Standardized approach for accurate and reliable model development of ion-exchange chromatography based on parameter-by-parameter method and consideration of extra-column effects [J]. Biotechnology Journal, 2024, 19(3): 2300687.

[11] Chen Yu-Cheng, Chen Xin-Yu, Lin Zhi-Yuan, Yao Shan-Jing, Lin Dong-Qiang*. Practical teaching of modeling tools for ion-exchange chromatography: A case study [J]. Journal of Chemical Education, 2023, 100(10): 3888–3896.

[12] Lin Dong-Qiang*^#, Chen Yu-Cheng^#, Chen Xin-Yu, Yao Shan-Jing. Exploration and practice of online-offline blended teaching in process simulation courses [J]. Journal of Chemical Education, 2024, 101(5): 1966–1973.

授權專利情況：

[1] 林東強, 陳煜成, 姚善涇. 層析機理模型和AI混合建模軟件, 軟件著作權登記號: 2025SR2387530 [P/OL]. 2025.

[2] 林東強, 陳煜成, 姚善涇. 空間質量作用模型校準軟件, 軟件著作權登記號: 2022SR1407855 [P/OL]. 2022.

[3] 林東強, 陳煜成, 姚善涇. 離子交換層析過程分析和模擬軟件, 軟件著作權登記號: 2020SR1886639 [P/OL]. 2020.

[4] 林東強, 楊宇翔, 陳煜成, 姚善涇. 基于PbP方法的離子交換層析過程分析和模擬軟件, 軟件著作權登記號: 2023SR0975789 [P/OL]. 2023.