教育工作經歷：

2017.08-至今 福州大學生物科學與工程學院，講師/副教授，碩士生導師

2020.02-2022.07 美國弗吉尼亞聯邦大學/密蘇里科技大學，博士后

2014.09-2017.07 中國科學院化學研究所，高分子化學與物理，博士

2011.09-2014.07 中國科學院化學研究所，材料工程，碩士

2007.09-2011.07 北京化工大學，高分子材料與工程，本科

教學簡介：

本科生課程：《生物醫學材料》、《藥物化學與分析》、《藥劑學》、《高分子與膠體化學》

研究生課程:《納米生物技術》、《藥物遞送系統》、《高分子與膠體化學》、《生物材料與組織工程》

科研簡介：

主要從事生物醫用材料的設計、制備及應用研究，包括（1）納米藥物遞送系統的構建及其在炎癥性疾病治療方面的應用；（2）醫用水凝膠的制備及其在抗感染傷口敷料、軟骨修復等方面的應用；（3）可降解醫用支架的制備及其在骨修復領域的應用；（4）檢測疾病標志物的生物傳感器的開發及應用。目前已在Angewandte Chemie International Edition、Advanced Functional Materials、Advanced Science、Biomaterials、Biosensors & Bioelectronics等本領域知名國際期刊上發表SCI論文60余篇，其中第一作者和通訊作者論文30余篇，授權發明專利5項，論文他引2000余次，H因子25。

社會兼職：

（1）2022.06至今，擔任Frontiers in Bioengineering and Biotechnology: Biomaterials期刊審稿編輯

（2）擔任Carbohydrate Polymers、International Journal of Pharmaceutics、Materials Today Bio、International Journal of Biological Macromolecules、Food Chemistry、Biomaterials Science、Journal of Materials Chemistry B等國際學術期刊審稿人

（3）福建省福州市/莆田市科技特派員。

科研項目：

（1）福建省口腔疾病研究重點實驗室開放課題，基于金屬多酚網絡的鈦種植體表面涂層的構建及其促骨結合研究，2026-2029，主持

（2）福建省科技創新聯合基金項目，負載黃芪甲苷-木犀草素的腎臟-線粒體雙靶向遞藥納米系統通過miR-34a/BNIP3調控線粒體自噬減輕糖尿病腎病的機制，2025-2028，聯合主持

（3）福建省自然科學基金面上項目，兼具活性氧清除和多藥遞送功能的羥乙基淀粉-姜黃素微粒的制備及其用于炎癥性腸病治療的研究，2023-2026，主持

（4）福建省自然科學基金青年項目，酸響應多級釋放納米載體用于抗癌藥物傳輸的研究，2019-2022，主持

（5）福建省教育廳中青年教師項目，姜黃素-茶多酚納米藥物的制備及應用，2018-2020，主持

（6）福州大學科研啟動經費，利用茶多酚制備疏水藥物的新型納米制劑的研究，2017-2020，主持

（7）技術開發項目，基于體表腫瘤、慢性創面與脂肪組織工程等整形外科亞專業的臨床與基礎研究，2023-2026，主持

（8）技術開發項目，納米均孔膜的均相電化學發光傳感器的技術開發，2023-2025，主持

（9）國家自然科學基金面上項目，高穩定性新型全無機無鉛鈣鈦礦納米材料的合成及應用，2023-2026，參與（第二）

（10）福建省科技廳合作項目，基于金納米團簇/二氧化鈦光催化材料的制備及其創面抗菌作用的研究，2022-2025，參與（第二）

代表性論文：（*為通訊作者）

1. Jiahao Du, Jinyi Mu, Minglang Zou, Yi Tang, Pengfei Wang, Zuquan Weng, Jiewei Luo, Da Huang.* Acid-labile liver-targeted unimolecular micelles based on hyperbranched polyprodrug amphiphiles for targeted therapy of hepatic fibrosis. Biomacromolecules 2026, 27, 895-905. IF=5.5 （中科院1區，Top期刊）

2. Lei Nie,* Qianqian Wei, Xiaoyue Ding, Lizhao Yan,* Jingyu Li, Wei Guo, Da Huang,* Oseweuba Valentine Okoro, Yanfang Sun, Guohua Jiang, Armin Shavandi. Schiff-base bioelectric and bioactive hydrogel dressing based on chitosan, alginate, and poly (N-isopropylacrylamide) for accelerating wound healing. International Journal of Biological Macromolecules 2025, 338, 149474. IF=8.4（中科院1區）

3. Yongming Wang, Yangcan Ming, Zhichao Yu, Zhenjin Xu, Minglang Zou, Cuiping Chen, Fang Luo, Da Huang,* Na Wang, Zhenyu Lin, and Zuquan Weng.* ROS-responsive cationic polymers with intrinsic anti-inflammatory activity for intracellular protein delivery. Biomacromolecules 2025, 26, 4, 2268-2281. IF=5.5 （中科院1區，Top期刊）

4. Minglang Zou, Cuiping Chen, Mingda Wang, Chen Lei, Yongming Wang, Fang Luo, Da Huang,* Meishui Wang, Houbing Zheng, Biao Wang,* Zhenyu Lin, Zuquan Weng.* Facile fabrication of injectable multifunctional hydrogels based on gallium-polyphenol networks with superior antibacterial activity for promoting infected wound healing. Advanced Healthcare Materials 2025, 14, 2404283. IF=10（中科院2區）

5. Binhui Wang, Bin Zhu, Yihao Liu, Bowen Ren, Yurong Chen, Luyao Feng, Sergio Martin-Saldana, Bochen An, Yining Gong, Yiming Ren, Jinqing Li, Da Huang,* Baoju Du,* Jianheng Liu,* Yazhong Bu.* Fast recoverable shape memory cryogels engineered with surfactant-stabilized bubbles and vermiculite for non-compressible hemostasis. Advanced Functional Materials 2025, 35, 2414340. IF=18.5（中科院1區，Top期刊）

6. Zhichao Yu, Zhenjin Xu, Ruijin Zeng, Man Xu, Minglang Zou, Da Huang,* Zuquan Weng,* Dianping Tang.* Tailored metal–organic framework-based nanozymes for enhanced enzyme-like catalysis. Angewandte Chemie International Edition 2025, 64, e202420200. IF=16.1（中科院1區，Top期刊）

7. Zhichao Yu, Zhenjin Xu, Ruijin Zeng, Man Xu, Haisu Zheng, Da Huang,* Zuquan Weng* and Dianping Tang.* D-band center engineered Pt-based nanozyme for personalized pharmacovigilance. Angewandte Chemie International Edition 2025, 64, e202414625. IF=16.1（中科院1區，Top期刊）

8. Da Huang, Pedro Norat, Lin Qi, Anna Chernatynskaya, James D. Cole, Vimalin Jeyalatha Mani, Lei Xu, Xiaorong Liu,* and Hu Yang.* Consistent intraocular pressure reduction by solid drug nanoparticles in fixed combinations for glaucoma therapy. Advanced Science 2024, 11, 2401648. IF=14.3（中科院1區，Top期刊）

9. Da Huang, Yongming Wang, Chenlan Xu, Minglang Zou, Yangcan Ming, Fang Luo, Zhenjin Xu, Ying Miao, Na Wang,* Zhenyu Lin, Zuquan Weng.* Colon-targeted hydroxyethyl starch-curcumin microspheres with high loading capacity ameliorate ulcerative colitis via alleviating oxidative stress, regulating inflammation, and modulating gut microbiota. International Journal of Biological Macromolecules 2024, 266, 131107. IF=8.4（中科院1區）

10. Da Huang, Jiahao Du, Fang Luo, Gang He, Minglang Zou, Yongming Wang, Zhenyu Lin,* Decheng Wu,* Zuquan Weng.* Injectable hydrogels with integrated pH probes and ultrasound-responsive microcapsules as smart wound dressings for visual monitoring and on-demand treatment of chronic wounds. Advanced Healthcare Materials 2024, 13, 2303379. IF=10（中科院2區）

11. Da Huang, Minglang Zou, Chenlan Xu, Yongming Wang, Zhenjin Xu, Wancong Zhang,* Shijie Tang,* and Zuquan Weng.* Colon-targeted oral delivery of hydroxyethyl starch-curcumin microcapsules loaded with multiple drugs alleviate DSS-induced ulcerative colitis in mice. Macromolecular Bioscience 2024, 24, 2300465. IF=4.6（中科院2區）

12. Da Huang,* Qiang Tang, Minglang Zou, Yongming Wang, Fang Luo, Jinyi Mu, Yuanzi Wu, Zuquan Weng* and Zhenyu Lin. Anti-inflammatory unimolecular micelles of redox-responsive hyperbranched polycurcumin amphiphiles with enhanced anti-inflammatory efficacy in vitro and in vivo. Polymer Chemistry 2023, 14, 5208-5217. IF=5.364（中科院2區）

13. Chenlan Xu, Shuting Chen, Cuiping Chen, Yangcan Ming, Jiahao Du, Jinyi Mu, Fang Luo, Da Huang,* Na Wang,* Zhenyu Lin and Zuquan Weng.* Colon-targeted oral nanoparticles based on ROS-scavenging hydroxyethyl starch-curcumin conjugates for efficient inflammatory bowel disease therapy. International Journal of Pharmaceutics 2022, 623, 121884. IF=6.51（中科院2區）

14. Fang Luo, Yating Zhang, Yexin Zu, Shiqing Li, Yiting Chen, Zhonghui Chen, Da Huang,* Bin Qiu, Zhenyu Lin.* Quick preparation of water-soluble perovskite nanocomposite via cetyltrimethylammonium bromide and its application. Microchimica Acta 2022, 189, 68. IF=6.408 （中科院2區）

15. Da Huang, Kristoffer Valerie, Hu Yang.* Clickable biocompatible brush polymers as a versatile platform toward development of multifunctional drug delivery vehicles. Reactive and Functional Polymers 2022, 170, 105147. IF=4.966 （中科院2區）

16. Fang Luo, Shiqing Li, Limei Cui, Yexing Zu, Yiting Chen, Da Huang,* Zuquan Weng, Zhenyu Lin.* Biocompatible perovskite quantum dots with superior water resistance enable long-term monitoring of the H₂S level in vivo. Nanoscale 2021, 13, 14297-14303. IF=8.307（中科院2區）

17. Shuting Chen, Jie Wu, Qiang Tang, Chenlan Xu, Yan Huang, Da Huang,* Fang Luo, Yuanzi Wu, Fen Yan, Zuquan Weng* and Shaoyun Wang. Nano-micelles based on hydroxyethyl starch-curcumin conjugates for improved stability, antioxidant and anticancer activity of curcumin. Carbohydrate Polymers 2020, 228, 115398. IF=10.723（中科院1區）

18. Jiamin Chen, Yi Lu, Fen Yan, Yuanzi Wu, Da Huang* and Zuquan Weng*. A fluorescent biosensor based on catalytic activity of platinum nanoparticles for freshness evaluation of aquatic products. Food Chemistry 2020, 310, 125922. IF=9.231（中科院1區）

19. Da Huang, Mi Sun, Yazhong Bu, Fang Luo, Cuiying Lin,* Zhenyu Lin, Zuquan Weng, Fei Yang* and Decheng Wu. Microcapsule-embedded hydrogel patches for ultrasound responsive and enhanced transdermal delivery of diclofenac sodium. Journal of Materials Chemistry B 2019, 7, 2330-2337. IF=7.571 （中科院2區）

20. Lixu Wang, Chaoqun Chen, Huawei Huang, Da Huang,* Fang Luo, Bin Qiu, Longhua Guo,* Zhenyu Lin and Huanghao Yang. Sensitive detection of telomerase activity in cancer cells using portable pH meter as readout. Biosensors & Bioelectronics 2018, 121, 153-158. IF=12.545 （中科院1區，Top期刊）

21. Da Huang, Yaping Zhuang, Fei Yang, Hong Shen, Xing Wang and Decheng Wu.* Acetal-linked PEGylated paclitaxel prodrugs forming free-paclitaxel-loaded pH-responsive micelles with high drug loading capacity and improved drug delivery. Materials Science & Engineering: C 2018, 82, 60-68. IF=8.457 （中科院2區）

22. Da Huang and Decheng Wu.* Biodegradable dendrimers for drug delivery. Materials Science & Engineering: C 2018, 90, 713-727. IF=8.457 （中科院2區）

23. Da Huang, Yaqiang Wang, Fei Yang, Hong Shen, Zuquan Weng and Decheng Wu.* Charge-reversible and pH-responsive biodegradable micelles and vesicles from linear-dendritic supramolecular amphiphiles for anticancer drug delivery. Polymer Chemistry 2017, 8, 6675-6687. IF=5.364（中科院2區）

24. Da Huang, Fei Yang, Xing Wang, Hong Shen, Yezi You and Decheng Wu.* Facile synthesis and self-assembly behavior of pH-responsive degradable polyacetal dendrimers. Polymer Chemistry 2016, 7, 6154-6158. IF=5.364 （中科院2區）

25.Da Huang, Dawei Li, Tiantian Wang, Hong Shen, Pei Zhao, Baoxia Liu, Yezi You, Yuanzheng Ma,* Fei Yang,* Decheng Wu* and Shenguo Wang. Isoniazid conjugated poly(lactide-co-glycolide): long-term controlled drug release and tissue regeneration for bone tuberculosis therapy. Biomaterials 2015, 52, 417-425. IF=15.304 （中科院1區，Top期刊）

獲獎情況

2026.02指導研究生獲2024屆省級優秀學位論文

2025.12指導研究生獲2025屆校級優秀學位論文（2人次）

2025.09指導研究生獲2024屆校級優秀學位論文（2人次）

2024.10指導研究生獲2024年研究生國家獎學金

2023.07獲福州大學2023屆優秀本科生畢業論文指導教師獎

2019.10指導研究生獲2019年研究生國家獎學金

其他

指導研究生多人赴中科院、廈門大學、華南理工大學等知名院校攻讀博士，進一步深造。

Researchgate個人主頁: https://www.researchgate.net/profile/Da-Huang-5