教育工作經歷：

2006.09-2010.07 中國農業大學 化學專業 學士

2010.09-2015. 07 國家納米科學中心 物理化學專業 博士

2015.08-2019.07 福州大學生物科學與工程學院 講師

2019.07-2025.08 福州大學生物科學與工程學院 副教授

2025.08至今 福州大學生物科學與工程學院 教授

科研簡介：

從事基于功能納米材料、功能核酸的生物探針構建以及在生物檢測、細胞生物學等領域的應用研究，包括活細胞熒光成像、細胞膜蛋白調控、腫瘤靶向檢測及診斷等。目前已在Journal of the American Chemical Society、Angewandte Chemie International Edition、Analytical Chemistry等國際刊物發表SCI論文20余篇。先后主持國家自然科學基金面上項目、福建省杰出青年科學基金、技術開發橫向合作項目等近10項，科研成果已實現成果轉化及應用。入選福建省第五批“雛鷹計劃”青年拔尖人才、福建省高層次C類人才、福州大學“旗山學者”。獲第八屆中國國際“互聯網+”大學生創新創業大賽銀獎、福建省“互聯網+”大學生創新創業大賽優秀創新創業導師、福州大學“青年五四獎章”、福州大學“杰出青年教師勵志獎”等榮譽稱號。

科研項目：

多級聯靶標響應型動態DNA納米探針用于原位肝癌活體成像，國家自然科學基金面上項目，2025-2028，主持。

活細胞表面特定蛋白糖基化類型的高通量分析及其分子識別性能的研究，國家自然科學基金面上項目，2020-2023，主持。

基于GaN納米結構的乳腺癌CTC分離及差異蛋白SALDI-MS分析研究，國家自然科學基金青年基金項目，2017-2019，主持。

活細胞膜蛋白功能分析及其應用，福建省杰出青年科學基金，2023-2026，主持。

基于硫醇交換遞送系統的納米藥物，技術轉讓，2021-2022，主持。

靶向腫瘤轉移節點分子的多模塊可編程納米藥物，國家重點研發計劃，2020-2025，參與。

代表性學術論文：

1. Zhijie Lian, Lingying Zheng, Shuya Liu, Junjie Zhang, Jie Zhou, Junjun Wu, Songying Ouyang, Jingying Li,* and Huanghao Yang*; Breaking Endosomal Barriers: Thiol-Mediated Uptake Lipid Nanoparticles for Efficient mRNA Vaccine Delivery, Journal of the American Chemical Society, 2025, 147, 31530?31540.

2. Shuya Liu, Shiwei Li, Jirong Lin, Jingying Li,* Huanghao Yang*; Aptamer-InducedDimerization Strategy Attenuates AβO Toxicity through Modulating the Trophic Activity of PrP^C Signaling, Journal of the American Chemical Society, 2022, 144(21): 9264-9270.

3. Shan Chen, Zhifei Xu, Shiwei Li, Hong Liang, Chen Zhang, Zonghua Wang, Jingying Li,* Juan Li, and Huanghao Yang*; Systematic Interrogation of Cellular Signaling in Live Cells Using a Membrane-Anchored DNA Multitasking Processor, Angewandte Chemie International Edition, 2022, 61, e202113795.

4. Jingying Li, Shuya Liu, Liqin Sun, Wei Li, Su-Yun Zhuang, Sheng Yang, Juan Li*, Huang-Hao Yang*; Amplified Visualization of Protein-Specific Glycosylation in Zebrafish via Proximity-Induced Hybridization Chain Reaction, Journal of the American Chemical Society, 2018, 140, 16589.

5. Shuya Liu, Dongliang Wang, Sishi Ye, Junjie Zhang, Beiyan Du, Zhijie Lian, Wen Yang, Jie Zhou, Qi Chen, Juan Li,* Jingying Li,* and Huanghao Yang*; Disulfide-Appended siRNA Nanoeyedrops:Noninvasive Gene Therapy for Targeting Retinal Angiogenesis, ACS Nano, 2025, 19, 35333?35347.

6. Lei Li,, Jing Hu, Wen Yang *, Jingying Li*; Tumor-specific glyco-detonators: A neuraminidase-3-gated programmable DNA Nanoarchitectonics for liver cancer-exclusive chemotherapy, Journal of Controlled Release, 2026, 390, 114495.

7. Shan Chen, Yufei Zhuo, Liying Pang, Hong Liang, Xiahui Lin,* and Jingying Li*; Photoactivatable DNA Conveyer Ferries Cellular Receptors to Lysosome for Collaborative Degradation in Zebrafish, ACS Applied Materials Interfaces, DOI: 10.1021/acsami.5c20326.

8. Shuya Liu, Lubin Han, Wen Yang, Bing Xiao, and Jingying Li*; Molecular-Specific Optical Coherence Tomography Contrast Agents for High-Sensitivity In Vivo Detection of Corneal Injury, ACS Sensors. 2025, 10, 9225-9231.

9. Shan Chen, Yufei Zhuo, and Jingying Li*; Nucleic Acid-based Protein Labeling Tools for Visualization of Membrane Receptors, Chem. J. Chinese Universities, 2025, 46(7), 20240567.

10. Junjie Zhang, Changkun Peng, Shuya Liu, Zhijie Lian, Jie Zhou, Jingying Li,* Huanghao Yang*; A Self-Assembled Transdermal Nanomedicines Incorporating Pendant Disulfides for Non-Invasive, Synergistic Treatment of Melanoma, Advanced Healthcare Materials, 2024, 13, 2402685.

11. Junjie Zhang, Weican Sun, Xing Wang, Senyan Chen, Jingying Li,* Huanghao Yang*; Thiol-mediated transportation pathway: an approach for improving tumor penetration of nanomedicines in vivo, Science China-Chemistry, 2024, 67, 383-389.

12. Jie Zhou, Junjie Zhang, Senyan Chen, Qinghua Lin, Rong Zhu, Liping Wang, Xiaole Chen, Jingying Li,* Huanghao Yang; Direct cytoplasmic delivery of RNAi therapeutics through a nonlysosomal pathway for enhanced gene therapy, Acta Biomaterialia, 2023, 170, 401-414.

13. Wen Yang, Zixiang Huang, Zhifei Xu, Xin Ma, Shan Huang, Jingying Li,* Juan Li, and Huanghao Yang; Selective and Nongenetic Peroxidase Tag of Membrane Protein: a Nucleic Acid Tool for Proximity Labeling, Analytical Chemistry, 2022, 94, 1101.

14. Wen Yang, Hexin Nan, Zhifei Xu, Zixiang Huang, Shan Chen, Jingying Li*, Juan Li, and Huanghao Yang*; DNA-Templated Glycan Labeling for Monitoring Receptor Spatial Distribution in Living Cells, Analytical Chemistry, 2021, 93, 12265.

15. Junjie Zhang, Hui Yang, Liang Li, Changkun Peng, and Jingying Li*; Noninvasive Transdermal Delivery of STING Agonists Reshapes the Immune Microenvironment of Melanoma and Potentiates Checkpoint Blockade Therapy Efficacy, ACS Applied Bio Materials, 2025, 8, 3156-3166.

16. Shuya Liu, Zhike Yan, Zixiang Huang, Huanghao Yang,* Jingying Li*; Smart Nanocarriers for the Treatment of Retinal Diseases, ACS Applied Bio Materials, 2024, 7, 2070?2085.

17. Lei Li, Jingying Li*; Dimerization of Transmembrane Proteins in Cancer Immunotherapy, Membranes, 2023, 13, 393.

18. Jingying Li, Liping Wang, Jinmiao Tian, Zhilan Zhou, Juan Li* and Huanghao Yang*; Nongenetic engineering strategies for regulating receptor oligomerization in living cells, Chemical Society Reviews, 2020, 49, 1545.

19. Jingying Li⁺, Tong Liu⁺, Shuya Liu, Juan Li*, Guoming Huang*, Huang-Hao Yang; Bifunctional magnetic nanoparticles for efficient cholesterol detection and elimination via host-guest chemistry in real samples, Biosensors & Bioelectronics, 2018, 120, 137.

20. Jingying Li⁺, Jie Zhou⁺, Tong Liu, Shan Chen, Juan Li* and Huanghao Yang*; Circular DNA: A Stable Probe for High Efficient mRNA Imaging and Gene Therapy in Living Cells. Chemical Communications, 2018, 54, 896.

21. Guoming Huang, Rui Liu, Yuehua Hu, Shi-Hua Li, Ying Wu, Yuan Qiu, Jingying Li*, Huanghao Yang; FeOOH-Loaded Mesoporous Silica Nanoparticles as A Theranostic Platform with pH-Responsive MRI Contrast Enhancement and Drug Release. Science China-Chemistry, 2018, 61, 806.